Differentially expressed PR-A and PR-B are co-localized with SRC-1 and SRC-2 in the female mouse hypothalamus
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Estradiol Preferentially Induces Progestin Receptor-A (PR-A) Over PR-B in Cells Expressing Nuclear Receptor Coactivators in the Female Mouse Hypothalamus
Estrogens act in brain to profoundly influence neurogenesis, sexual differentiation, neuroprotection, cognition, energy homeostasis, and female reproductive behavior and physiology through a variety of mechanisms, including the induction of progestin receptors (PRs). PRs are expressed as two isoforms, PR-A and PR-B, that have distinct functions in physiology and behavior. Because these PR isofo...
متن کاملEstradiol Preferentially Induces Progestin Receptor-A (PR-A) Over PR-B in Cells Expressing Nuclear Receptor Coactivators in the Female Mouse Hypothalamus1,2,3
Estrogens act in brain to profoundly influence neurogenesis, sexual differentiation, neuroprotection, cognition, energy homeostasis, and female reproductive behavior and physiology through a variety of mechanisms, including the induction of progestin receptors (PRs). PRs are expressed as two isoforms, PR-A and PR-B, that have distinct functions in physiology and behavior. Because these PR isofo...
متن کاملExpression of Nuclear Receptor Coactivators in the Brain of Progestin Receptor Isoform-specific Knock-out Mice
The ovarian steroid hormones estradiol (E) and progesterone (P) play important roles in reproductive physiology and behavior. The effects of E and P are mediated by their respective receptors, estrogen receptor (ER) and progestin receptor (PR) which function as transcription factors. PR is expressed as two isoforms, full length PR-B and the N-terminally truncated PR-A, by the induction of E in ...
متن کاملNuclear receptor coactivators are coexpressed with steroid receptors and regulated by estradiol in mouse brain.
BACKGROUND/AIMS The steroid hormones, including estradiol (E) and progesterone, act in the brain to regulate female reproductive behavior and physiology. These hormones mediate many of their biological effects by binding to their respective intracellular receptors. The receptors for estrogens (ER) and progestins (PR) interact with nuclear receptor coactivators to initiate transcription of stero...
متن کاملSteroid receptor coactivator 2 is required for female fertility and mammary morphogenesis: insights from the mouse, relevance to the human
Although the importance of the progesterone receptor (PR) to female reproductive and mammary gland biology is firmly established, the coregulators selectively co-opted by PR in these systems have not been clearly delineated. A selective gene-knockout approach applied to the mouse, which abrogates gene function only in cell types that express PR, recently disclosed steroid receptor coactivator 2...
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